Are SARMs Liver Toxic? #4 & #5 Are!

Selective Androgen Receptor Modulators (SARMs) are gaining popularity in the fitness community for their ability to enhance muscle growth and performance.

However, a common question arises: Are SARMs liver toxic?

This article dives deep into the hepatotoxicity of SARMs, comparing them with steroids and providing evidence from scientific studies.


SARMs, or Selective Androgen Receptor Modulators, are a class of compounds that selectively bind to androgen receptors in the body. Unlike anabolic steroids, SARMs target specific tissues, potentially reducing unwanted side effects.

Are SARMs Liver Toxic?

The hepatotoxicity of SARMs varies depending on the specific compound. Here’s a detailed table summarizing the liver toxicity of various SARMs:

SARMLiver ToxicityReference
Ostarine (MK-2866)LowStudy on Ostarine
Ligandrol (LGD-4033)LowStudy on Ligandrol
Testolone (RAD-140)Low to ModerateStudy on Testolone
YK-11Potentially HighStudy on YK-11
S23Moderate to HighStudy on S23
Andarine (S4)ModerateStudy on Andarine
Cardarine (GW-501516)Potentially HighStudy on Cardarine

How Do SARMs Compare to Steroids in Terms of Liver Toxicity?

Anabolic steroids are well-known for their significant impact on liver health. Liver toxicity from steroids can lead to conditions like cholestasis, hepatocellular injury, and even liver cancer.

SARMs are designed to have a more targeted action, which potentially reduces their impact on the liver.

However, the risk of liver toxicity cannot be completely ruled out, especially with higher doses and prolonged use.

CompoundLiver Toxicity LevelCommon Liver Issues
Anabolic SteroidsHighCholestasis, hepatocellular injury, liver cancer
SARMs (general)Low to ModerateElevated liver enzymes, potential hepatotoxicity

Relevant Studies and Findings

  1. Enobosarm (Ostarine) Study:
    • Study: Drug-Induced Liver Injury from Enobosarm.
    • Findings: Shows low hepatotoxicity with recommended doses. Link to Study
  2. LGD-4033 Study:
    • Study: Clinical evaluation of Ligandrol in healthy males.
    • Findings: No significant liver toxicity at recommended doses. Link to Study
  3. RAD-140 Study:
    • Study: Hepatotoxicity of Testolone.
    • Findings: Low to moderate liver toxicity, elevated liver enzymes reported. Link to Study

Practical Tips to Mitigate Liver Toxicity

  • Follow recommended doses: Avoid excessive dosages to minimize liver stress.
  • Regular liver function tests: Monitor liver enzymes periodically.
  • Avoid alcohol: Alcohol can exacerbate liver damage.
  • Use liver support supplements: Consider supplements like milk thistle or N-acetyl cysteine.


Are SARMs liver toxic? The answer is nuanced.

While SARMs are generally considered to have lower hepatotoxicity compared to anabolic steroids, they are not completely free of liver-related risks. It’s crucial to use them responsibly, adhere to recommended dosages, and monitor liver health regularly.



Q1: Can SARMs cause liver damage?

  • Yes, but the risk is generally lower than with anabolic steroids.

Q2: How can I protect my liver while using SARMs?

  • Follow recommended dosages, avoid alcohol, and consider liver support supplements.

Q3: Are there any SARMs with no liver toxicity?

  • Most SARMs have some level of liver toxicity, but compounds like Ostarine (MK-2866) and Ligandrol (LGD-4033) have lower risks.
Scroll to Top