LGD 4033 vs 3303: A Detailed Comparison

Both LGD 4033 and LGD 3303 are selective androgen receptor modulators (SARMs) developed by Ligand Pharmaceuticals aimed at treating conditions like muscle wasting and osteoporosis.

Despite their similar names, these SARMs exhibit distinct properties and effects. This article aims to delve into LGD 4033 vs 3303, providing a comprehensive comparison based on scientific data, anecdotal evidence, and a practical guide on their use.

lgd 4033 vs 3303 featured image
AspectLGD 4033LGD 3303
Research & DataMore thoroughly researched with clinical trialsLacks clinical trials, mainly anecdotal evidence
Muscle BuildingEffective for bulking, causes some water retentionStronger, dry gains, best for lean muscle mass
Strength & PerformanceGood increase in strengthSuperior strength gains
Bones & JointsIncreases bone density, beneficial for jointsIncreases bone density, less joint support
RecoverySpeeds up recovery, but less effective than LGD 3303Fastest recovery rates
Cosmetic ImpactCauses rapid size increase, less vascularityPromotes hard and grainy appearance
Side EffectsLower risk compared to LGD 3303Higher potential for severe side effects
Testosterone SuppressionManageable suppression levelsPotentially complete shutdown of natural testosterone

LGD 4033 is more thoroughly researched, with multiple clinical studies supporting its efficacy in muscle building and safety.

It is primarily used by those looking to gain significant muscle mass while also benefiting from increased bone density and joint support.

For more insights on LGD 4033, visit our detailed guide.

In contrast, LGD 3303 is relatively newer and lacks comprehensive clinical data.

However, its anecdotal reports suggest impressive muscle-building capabilities, often described as the strongest SARM for lean muscle mass.

Learn about users’ 30-day results with LGD 4033 here.

Muscle Building and Strength

LGD 4033 is popular among beginners and intermediate users due to its efficacy and lower risk of severe side effects.

It’s well-known for bulking phases where significant weight gain is desired, albeit with some water retention. Check out the typical dosages here.

LGD 3303, on the other hand, stands out in muscle building and strength enhancement.

It offers dry, hard gains with no water retention, making it ideal for those aiming for a shredded appearance.

However, its potent nature means it’s better suited for advanced users.

lgd 4033 vs 3303 side effects and testosterone suppression

Side Effects and Testosterone Suppression

Both SARMs exhibit side effects typical of androgen receptor modulators, such as testosterone suppression and potential impacts on cholesterol and liver health.

LGD 4033 causes less severe side effects, which can often be managed without aggressive post-cycle therapy (PCT). For PCT options, visit our PCT guide.

LGD 3303 might require a more stringent PCT protocol, due to its higher suppression rates.

Users are advised to prepare for a full PCT with comprehensive support, possibly including multiple selective estrogen receptor modulators (SERMs).

For more info on powerful SERMs like Tamoxifen, check our Tamoxifen guide here.

Practical Usage

Both SARMs should ideally be used in bulking cycles to maximize their muscle-building potential.

LGD 4033 is more forgiving and can be a good choice for those new to SARMs or looking for moderate gains with manageable side effects.

On the other hand, LGD 3303 requires more experience to handle its powerful effects and potential side effects.


Choosing between LGD 4033 and LGD 3303 depends largely on your experience level, desired gains, and willingness to manage potential side effects.

LGD 4033 offers a safer profile with substantial benefits, making it ideal for most users, while LGD 3303 caters to those seeking maximum muscle growth and can manage its intense effects.

For further reading and real user experiences, visit this Reddit discussion.

For more detailed information on the development and studies regarding these SARMs, you can check Ligand Pharmaceuticals’ press release.

Frequently Asked Questions


Which is better for muscle building, LGD 4033 or LGD 3303?

LGD 3303.

LGD 3303 is generally considered stronger for building lean muscle mass, offering dry gains with no water retention, while LGD 4033 is effective for bulkier, water-retained muscle growth.

Are there any clinical trials supporting LGD 3303?


As of now, LGD 3303 lacks clinical trials and most information available is based on anecdotal evidence, unlike LGD 4033 which has been more thoroughly researched.

What are the main side effects of LGD 4033 and LGD 3303?

Testosterone suppression.

Both SARMs can suppress natural testosterone production, affect cholesterol levels, and increase liver enzymes. LGD 3303, however, tends to have more pronounced side effects due to its potency.

Can LGD 3303 be used for cutting?


While LGD 3303 can be used on a caloric deficit, its muscle-building potential is best utilized during bulking cycles. It is not typically recommended for cutting as its strengths lie in mass gain.

What type of post-cycle therapy is recommended after using LGD 4033 or 3303?

Tamoxifen or Enclomiphene.

For LGD 4033, a milder PCT might suffice, and in some cases, users can avoid it at low doses. LGD 3303 usually requires a more comprehensive PCT due to its higher testosterone suppression. Check our detailed PCT guide for more information.

Where can I find trusted sources to purchase LGD 4033 and LGD 3303?

It is crucial to purchase SARMs from reliable vendors. Visit our SARMS SOURCES page for vetted suppliers known for their quality and service.

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