Our AIs: A Quick Guide!
Read all you need to know about the AIs we offer and how to use them for your research!
AI? What Is That?
Aromatase inhibitors (AIs) are a class of medicines that work by blocking the enzyme aromatase, the enzyme that converts androgens into estrogen.
We use aromatase inhibitors in the treatment of breast cancer to reduce levels of circulating estrogen.
So they lower estrogen levels by stopping an enzyme in fat tissue from changing other hormones into estrogen.
There are three aromatase inhibitors: anastrozole, exemestane, and letrozole.
Since AIs lower estrogen, they are an excellent way to help in the fight against gynecomastia. By blocking estrogen, these kinds of breast tissue will not be able to grow.
Why Should You Use An AI?
There are a few reasons why you should use an AI. The most obvious one is to block out estrogen.
In the case of research purposes, AIs can be very helpful in some situations.
We all know we need estrogen in the body for several reasons (strong bones, healthy joints, sexual performance…).
But we also know that too high estrogen levels can be very counterproductive for research purposes.
In most cases, the body is very efficient in regulating the balance of our testosterone/estrogen levels, but there are some situations where the body might need some help.
Highly Aromatising Compounds
When you start your research with a (or more) highly aromatizing compound, you should get an AI right away as a research auxiliary.
Aromatizing compounds will cause estrogen levels to rise too much to regulate them properly.
This means estrogen levels will be sky high and testosterone/estrogen balance will be out of balance.
As these compounds keep lowering testosterone levels, the research subject will be extra vulnerable to these high estrogen levels down the research and especially after the research.
So always check for the aromatizing nature of the compound. If it does aromatize, be sure to have an AI on hand.
Stacking Suppressive Compounds
When stacking suppressive compounds, this means that exogenous testosterone will rise very strong.
The excess of incoming testosterone in the test subject will cause a serious drop in SHBG and will kick endogenous testosterone out of androgen receptors.
The effect of this will cause a boost in free testosterone. This overload of free testosterone will aromatize causing estrogen levels to go way up.
In this case, it will be very useful to have an AI on hand for the first weeks of the research to counteract this situation.
When Should You Use An AI?
This is more about the timing than about in which situations.
The use of an AI will be pretty much the same in all of these above situations.
- Use the AI once a day at the same moment
- AI is needed especially at the start of your research
- Only use an AI when needed
Pretty simple, right.
AIs are dosed once a day so that’s the easy part.
As we mentioned before the moment you will need an AI will be in most cases at the beginning of the research. When using highly aromatizing compounds you will need it throughout the research.
If one of the above situations is applicable to your type of research: you need an AI on hand.
The AIs We Have For Your Research
Anastrozole (a.k.a. Arimidex) is FDA approved to treat postmenopausal women with breast cancer that responds to estrogen-receptor treatment. It is primarily used to treat women with advanced disease progression, especially if they have received tamoxifen treatment before. It can also be used as first-line therapy as well.
The dosage for Arimidex is 1 mg once daily with or without food.
Exemestane (a.k.a. Aromasin) is FDA approved to treat estrogen-receptor-positive breast cancer in postmenopausal women after 2 to 3 years of tamoxifen therapy. It is primarily used to treat the advanced progression of breast cancer after tamoxifen treatment has failed.
The dosage for Exemestane is 25 mg once daily after food intake.
Which One Should You Pick?
Both of these products are FDA approved so they both are safe to use.
They are very similar so have the same benefits and almost the same side effects.
They both block out aromatizing in a very efficient way.