PRT 101 – Handling Suppression – Part 1
A short and simple explanation about how to handle testosterone suppression after your research!
PRT: What Is That Again?
Post Research Therapy is a protocol that combines specific supplements or other compounds to enhance and restore testosterone levels after research.
Every performance enhancing compound starts to suppress testosterone production.
Technically speaking, natural hormones get replaced by synthetic compounds.
That means that once you stop administering them to your test subject, those synthetic compounds will leave the test subject’s system immediately.
From there on, the body’s natural hormones will have to start working again.
But, it might require assistance to start working at a hundred percent again.
This is because they’ve been inactive for months, meaning they’re going to need some help.
That’s where the choice of good PRT auxiliaries is very important.
And that’s exactly why you’ll need good post research therapy.
When we talk about suppression in terms of research with our products, we will always mean testosterone suppression.
Let us explain that again.
When researching with our compounds, most of these compounds bind to the ARs ( androgen receptor) in the body.
While these receptors keep getting stimulated, the body gives the signal to produce less testosterone.
Why? Because the ARs are already overstimulated so that means the same testosterone production is not needed anymore.
That’s the simple explanation.
The more profound explanation is this:
SARMs have shown to suppress luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through the hypothalamus-pituitary-testis axis, thus decreasing testosterone in a dose-dependent manner.
They also suppress Sex hormone-binding Globulin (SHBG) and total testosterone levels.
LH is responsible to stimulate the testes to produce testosterone
Because of that, a drop in LH level will also cause a drop in testosterone production thus it causes suppression.
The extent to which LH production is inhibited is dependent on how suppressive the exogenous compound is that you are introducing into the test subject, as well as the dose of it, and the duration of its’ use.
So in other words, higher doses and longer research will cause more suppression in general.
What Kind Of PRT Auxiliaries For Handling Suppression?
As we said, the main goal in a PRT is to restart testosterone production to a normal natural level.
In a PRT we do this by stimulating LH. A higher (normal) level of LH will stimulate the testes to produce the right amount of testosterone again.
This is where SERMs come into action.
SERMs can stimulate endogenous Testosterone production in males by blocking the hypothalamic estrogen receptor.
This tricks the brain into thinking that estrogen levels are low.
To produce more estrogen the body needs enough testosterone to aromatize to estrogen.
So the body will tell the hypothalamus to stimulate the release of LH and FSH.
That’s how a SERM restores natural testosterone levels.
Clomid (Clomiphene Citrate) is a powerfully effective anti-estrogen. It is still the most popular SERM.
It has the ability to oppose the negative feedback of estrogens on the Hypothalamic-Pituitary-Ovarian-Axis. This will increase the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH).
It is very similar to Clomiphene in how it works in the body.
For its anti-estrogen properties, it binds better to the mammary tissue. This means Tamoxifen is better at stopping gynecomastia from the very start!
That’s the biggest difference with Clomiphene.
Fights and stops gynecomastia from the start
Boosts testosterone (less pronounced than Chlomid)
Less annoying side effects than Clomiphene
It works very similarly to both Clomiphene and Tamoxifen, but there is less ‘clinical’ data.
Raloxifene is less effective in boosting testosterone levels again compared to Clomiphene and Tamoxifen.
On the other hand, it’s highly effective in fighting gyno and it even can reverse long-existing gynecomastia!
So maybe not your ideal choice as a PRT on its own but you can definitely add it to Clomiphene or Tamoxifen as an extra!
Prevents and reverses gyno
A mild increase in testosterone levels
No particular side effects
Yes, you read it right.
We are adding Enclomiphene to our SERMs in the very near future.
Enclomiphene is the only SERM that is being primarily studied as a treatment for hypogonadism. It is extremely effective at boosting testosterone levels.
It is also extremely effective at increasing fertility and sperm count.
Enclomiphene can as well be used as a testosterone booster and a test base.
It’s best compared to Clomiphene.
Boosts testosterone (maybe even more than Clomiphene)
May boost sex drive and sexual performance
Might lower IGF-1 in long term but that is the only side effect!
So don’t hesitate
As you can see, we have everything in stock for a succesful PRT.
Our SERMs are of the highest quality you can find.
What is a good PRT?
We will explain that in part 2 of this article. Coming up later this week!
Keep an eye on part 2 of this topic. Will be available very soon in our knowledge vault!