S-23 SARM: REVIEW, DOSAGE, PCT & MORE IN 2023

WHAT IS S-23?

S-23 is perhaps the most powerful cutting SARM on the market today. Despite seeming very promising and attractive on paper, S-23 is quickly becoming one of the least popular and most overlooked drugs in its category, with people choosing other SARMs and oral AAS instead.

It was developed by GTx, Inc. but unlike other SARMs by this company, it was not developed to treat muscle wasting conditions or osteoporosis. Instead, it was developed as a potential form of oral contraception for males. It never reached clinical trials, so we have no scientific data about the effects of S-23 on humans.

BUY S-23

Click on the link below to buy our recommended S-23) and save 10% OFF with code ENH10 at checkout!
BUY S-23 SARM

BUY S-23

Click on the link below to buy our recommended S-23 and save 10% OFF with code ENH10 at checkout!

S-23 SARM HISTORY

The pharmaceutical company responsible for the development of S-23 is GTx, Inc (they’re quite responsible for a lot of SARMs, actually). They originally developed it as a male contraceptive approximately 15 years ago. Since then, it has been forgotten.

In a 2008 in vitro study (test tubes) with castrated rats, S-23 showed a dose-dependent improvement in total lean body mass, increased bone density, reduced fat mass, and was well tolerated. [R]

HOW TO BUY S-23 LEGALLY

S-23 is a SARM and is a legal performance enhancing drug. Given that is has not been approved by the FDA, S-23 can be classified as a research chemical. Research chemicals are completely legal to buy and sell online and over-the-counter, as long as they are being marketed as research products for laboratory use only and not for human consumption.

You can find high-quality, 3rd-party purity-tested S-23 SARM for SALE by clicking in the link below. Use code ENH10 to save 10%!

HOW DOES the S-23 SARM WORK?

Like all SARMs, S-23 works by attaching to the androgen receptor in muscle tissue and bones. There, it stimulates protein synthesis to accelerate muscle growth and bone density. 

This mechanism of action is similar to that of Anabolic Steroids, but the difference is that Anabolic Steroids are not selective and they attach to androgen receptors in all kinds of tissues, whereas SARMs are as selective for muscle and bone mass as possible.

MECHANISM OF ACTION OF SARMS

S-23 PROS & CONS IN A NUTSHELL

PROS:

  • VERY ANABOLIC
  • WILL IMPROVE STRENGTH NOTICEABLY
  • WILL PROVIDE A DRY, HARD AND VASCULAR LOOK
  • WILL INCREASE BONE DENSITY AND JOINT STRENGTH

CONS:

  • WILL SUPPRESS TESTOSTERONE LEVELS (TO A SMALL EXTENT COMPARED TO OTHER ANABOLICS)
  • WILL CAUSE DYSLIPIDEMIA
  • MAY CAUSE MILD LIVER TOXICITY
  • WILL CAUSE INFERTILITY

BENEFITS OF S-23

The benefits of S-23 have turned this male contraceptive into a great performance enhancing drug and anabolic for intermediate and advanced enhanced lifters.

These are the main benefits of S-23:

FAST MUSCLE GROWTH

It is hard to quantify how much muscle S-23 can help you gain because it is rarely used as a bulking compound. People who use it on a modest caloric deficit report a decent increase in muscle mass.
 
Still, the anecdotal data we have reviewed regarding its use during bulking cycles seems to indicate that S-23 is very anabolic and comparable to SARMs like Ligandrol (LGD-4033) and Testolone (RAD-140) in terms of lean mass accrual. [R]
 

STRENGTH INCREASE

The anecdotal data about the performance enhancing benefits of S-23 we have is very contradictory. On the one hand, we have people experiencing a very significant increase in muscle mass and performance whether they are bulking up or cutting fat.

On the other hand, we have people who experience a serious drop in strength and performance when cutting, partly due to S-23 being harsh on the joints and partly due to the alleged ability of S-23 to rapidly burn through glycogen, something that leaves users feeling extremely depleted and looking seriously flat. [R]
 

FAT LOSS

Pre-clinical animal studies on S-23 claim that this compound can burn fat on a dose-dependent manner.

We cannot extrapolate this information and confirm that this phenomenon applies to humans as well, but many users claim that S-23 increases metabolism so much, that it can boost fat loss. Take that information with a grain of salt. [R]
 

INCREASE BONE DENSITY & JOINT STRENGTH

S-23, like all SARMs, will increase the density of your bones and it will make them stronger. Unfortunately, it tends to mistreat joints and tendons, making users more prone to getting injured. [R]
 

RECOVERY

Like any proper anabolic, S-23 will speed up recovery times and reduce muscle soreness, allowing you to train specific muscle groups again much sooner.
 

COSMETIC BENEFITS

The cosmetic benefits of S-23 are the main reason why so many people choose to take it despite the risks associated with it.

From reviewing anecdotal information, we can see that the cosmetic benefits are like those of steroids such as Winstrol and Masteron, so one can expect an extremely dry and vascular look when cycling S-23.

Unfortunately, the muscle flatness that it can cause in the absence of sufficient carbohydrates can compromise the look of users who are trying to look fuller and bigger.
 

OTHER BENEFITS

 

CONTRACEPTION AND SEXUAL DESIRE

Some people welcome the contraceptive effect of S-23, while others fear it and consider it a dangerous side-effect. More information about this in the “SIDE-EFFECTS” section.

It is also worth noting that S-23 sexual desire in female rats, so it may be able to do the same in humans. Make of that what you will.
[R] [R]

SIDE-EFFECTS S-23

Unfortunately, S-23 is not side-effect-free. The amazing benefits you just learned about come with some potentially harsh negatives.

TESTOSTERONE SUPPRESSION

All SARMs can potentially cause testicular shutdown if taken in extreme amounts during large periods of time, but S-23 will cause complete shutdown even at small dosages taken for short periods of time. This is normal, given that it was developed as an oral contraceptive and dropping LH and FSH levels to 0 is necessary in order to achieve that. Keep in mind that in most cases S-23 on its own will not cause infertility.
Since S-23 will crash your Testosterone down to a negligible level, there will be no conversion of Testosterone into Estrogen and you will feel like complete garbage throughout the cycle UNLESS you are running a Testosterone base of some sort; this also makes a PCT mandatory (More on that in the chapter about On-Cycle Therapy and Post-Cycle Therapy).
The consequences of this drop in your testosterone levels can be:
  • Decreased libido
  • Weaker erections
  • Lethargy
  • Lack of motivation
  • Irritability
  • Testicular atrophy
  • Testicular pain
Thankfully, most users do not experience more than a couple of these and only for a very limited amount of time, usually by the end of the cycle and during the first week or two after the cycle is over.
It is worth noting that S-23, like all SARMs, will decrease your SHBG. This will lead to an increase in your free testosterone levels which usually causes libido, motivation and well-being to improve during the first few weeks of the cycle, until the suppression of the Total Testosterone levels offsets the increase in Free Testosterone. [R]
 
Anecdotal bloodwork provided by users confirms the effectiveness of S-23 at crashing LH and FSH levels, therefore we can conclude that it is an effective oral contraceptive for men (you should still use condoms, though).
 

DYSLIPIDEMIA

S-23, like all SARMs, will cause dyslipidemia. By the end of the cycle, your HDL (good) cholesterol will be significantly lower and your LDL (bad) cholesterol will have sky-rocketed.
This side-effect will not manifest itself by impacting the way you feel, so you will have no symptoms. Getting bloodwork at the end of a cycle will show the true impact of the SARM on your lipid panel.
 

LIVER TOXICITY

Even though there is no scientific evidence to prove that S-23 is hepatotoxic in humans, anecdotal reports almost always show a significant increase in liver enzyme levels.
 

ANDROGENIC SIDE-EFFECTS

On paper S-23 should not be androgenic, but hundreds of users report androgenic side-effects such as hair loss, acne and aggression. It is unclear why S-23 has androgenic properties.

INCREASED BODY TEMPERATURE

Some users report increased body temperature, so excessive sweating, night sweats, dehydration and cramps can easily happen.

 

OTHER SIDE-EFFECTS

The five side effects we just touched upon will impact almost every user, but there are some side effects that only happen to an extremely small minority of people.

Gynecomastia

The growth of breast tissue on males. This is an extremely rare side effect that is caused by an imbalance between your estrogen and testosterone levels. Men who have had pubertal gynecomastia are at risk of developing it if they take S-23.
 

Hair shedding

This side effect is even rarer than the previous one, and thankfully it only seems to be temporary and completely reversible. Any substance that interferes with your hormonal levels has the potential of causing hair shedding, and S-23 is no exception.

Insomnia

This is another rare side-effect that some people experience. This one is entirely unpredictable but can be mitigated easily.
SARMs impact everyone differently. You may become infertile, and your friend may impregnate his girlfriend during a cycle of S-23.
 

HOW TO AVOID & REVERSE SIDE-EFFECTS

Managing the side-effects of S-23 during a cycle is easier than it seems. Having a clean diet, doing your cardio, avoiding alcohol and sleeping right will help a lot but some rare possible side-effects like man boobs, hair loss, and acne require special protocols.
 

AVOIDING SIDE-EFFECTS

If you are planning to do an S-23 cycle and you want to make sure your results are as good as possible while minimizing all side-effects and preventing the nasty side-effects like testosterone shutdown, erectile dysfunction, and hair-loss, you need to read THE SARM HANDBOOK by @enhancedinfo.
 
This best-selling eBook by enhancedinfo has truly become the No.1 book about SARMs ever written, with over 7000 copies sold and close to 300 5-star reviews, all for the price of a basic menu at McDonalds. Click on the link below to read it!

S-23 SARM DOSAGE FOR BODYBUILDING

Bodybuilders use anywhere from 10mg to 30mg a day of S-23 but the sweetspot that most male users prefer is 20mg a day. Do your due diligence to remember the half-life of S-23 is unclear but most take it twice per day. For example, if you choose 20mg/day as your dose, you would take 10mg every 12 hours.

Female users can get amazing results with as little as 10mg a day, and they should never use more than 20mg a day.

HOW TO CYCLE S-23

The most common S-23 cycle consists of 20mg, split twice a day, taken for a total of 8 weeks. The shortest S-23 cycles are usually around 4 weeks and the longest ones can last for up to 10 weeks. 

We really believe that 20mg a day for 8 weeks is the best approach to using S-23, since it’s a protocol that allows most people to get amazing results without experiencing seriously nasty side-effects.

These cycles are usually followed by a 4 week Post-Cycle Therapy.

S-23 ON-CYCLE THERAPY

It’s imperative you use a testosterone base with your S-23.

We can’t recommend Amino Asylum Enclomiphene enough. While using S-23, a simple 12.5mg/day protocol of Enclomiphene can help keep your testosterone levels balanced, not causing any of the nasty symptoms from suppression or worse, a crash.

They were generous enough to give our community a 20% discount on all purchase. Use code ENHANCED20 at checkout to save on your entire cart.

S-23 POST-CYCLE THERAPY (PCT)

Since S-23 can suppress testosterone levels to a potentially large extent or even cause a shutdown, we recommend all users to do a Post-Cycle Therapy (PCT) after a S-23 cycle to restore natural testosterone levels and ensure the retention of muscle gains, strength, and optimal sexual function.

The typical S-23 PCT consists of 4 weeks of Clomiphene (Clomid) or Enclomiphene (Androxal) use. You can learn more about the ideal PCT for SARMs here.

S-23 SARM TL:DR

In a nutshell, we could say that S-23 is an incredibly effective SARM that will build a modest amount of muscle mass and strength.

This is an excellent option for intermediates who want to get their feet wet with stronger PEDs but also for experienced, enhanced lifters who simply want to use something milder than an AAS (Steroid) that will still provide great results.

Take S-23 2x per day every 12 hours.

WHERE TO BUY S-23

If you decide to research with the S23 SARM, choosing a reliable company to buy from is crucial, since buying it from a bad company could result in you getting no results or getting horrible side-effects due to being sold something that’s not actually S-23.

We recommend going with Chemyo’s S-23 SARM.

All of their SARMs vials come in 50 ml (milliliter) bottles, which is a full 20 ml more than the industry standard of 30 ml—that’s a 66% increase in the value you’re getting with these products.

Key benefits of Chemyo:

  • Third Party Testing
  • Very Good Prices
  • Responsive Customer Support
  • Wide Range of Products
  • Big Cryptocurrency Discount

They have been in the game for half a decade and have truly become one of the most reputable and most respected providers for 99.9% pure SARMs and other research chemicals.

You can buy S-23 from them through the link below and use code ENH10 to save 10% off your order

S-23 FAQs

Scroll to Top