2 Facts About SARMs and Blood Pressure You Need to Know

Selective Androgen Receptor Modulators (SARMs) have gained popularity for their muscle-building and fat-burning benefits. However, SARMs and blood pressure is a topic that demands attention. Understanding how SARMs affect your cardiovascular health is crucial for safe usage.

SARMs and blood pressure

SARMs can influence blood pressure in several ways. While they are often marketed as safer alternatives to anabolic steroids, some users have reported elevated blood pressure during their cycles.

This can be attributed to various factors including fluid retention, increased red blood cell count, and hormonal changes.

Key Points:

  • Fluid Retention: Some SARMs can cause the body to retain water, leading to an increase in blood pressure.
  • Increased Red Blood Cell Count: Higher levels of red blood cells can thicken the blood, making the heart work harder to pump it.
  • Hormonal Changes: SARMs can affect hormones that regulate blood pressure, potentially leading to hypertension.
CompoundTypePotential Blood Pressure ImpactNotes
OstarineSARMMildGenerally well-tolerated
RAD-140SARMModerateUsers report some increase
LGD-4033SARMModerateCan cause fluid retention
MK-677Non-SARMHighKnown for significant water retention
YK-11SARMModerate to HighLimited studies available
S23SARMHighStronger androgenic effects
CardarineNon-SARMLow to NoneGenerally safe for blood pressure
SR9009Non-SARMLow to NoneKnown to improve cardiovascular health

Relevant Studies and Facts

  1. Study on SARMs and Cardiovascular Health: A study published in the Journal of Clinical Endocrinology examined the effects of SARMs on cardiovascular health. The study found that certain SARMs could lead to an increase in blood pressure, particularly those that cause significant fluid retention (r).
  2. MK-677 and Blood Pressure: Research on MK-677, a growth hormone secretagogue, indicates a notable increase in water retention and blood pressure. This makes it crucial for users to monitor their cardiovascular health closely (r).

Managing Blood Pressure While Using SARMs

If you’re considering or currently using SARMs, there are steps you can take to manage your blood pressure:

  • Regular Monitoring: Keep track of your blood pressure regularly to detect any significant changes early.
  • Hydration: Maintain proper hydration levels to help manage fluid retention.
  • Diet: Eat a balanced diet low in sodium to support cardiovascular health.
  • Exercise: Engage in regular cardiovascular exercise to help maintain healthy blood pressure levels.
  • Consult a Healthcare Provider: Before starting any SARM cycle, consult with a healthcare provider, especially if you have a history of hypertension or other

Drugs That Can Help Reduce Blood Pressure: An Overview

In addition to understanding the impact of SARMs on blood pressure, it’s essential to know about other drugs that can help manage hypertension. Some drugs, originally developed for other conditions, have shown effectiveness in lowering blood pressure. Here, we’ll discuss Tadalafil, Sildenafil, and other notable medications.

Tadalafil and Sildenafil: Beyond Erectile Dysfunction

Tadalafil (Cialis) and Sildenafil (Viagra) are well-known for treating erectile dysfunction. However, they also have significant effects on the cardiovascular system, making them useful for managing blood pressure.

How They Work:

  • Mechanism: Both drugs are phosphodiesterase type 5 (PDE5) inhibitors. They work by relaxing blood vessels, which increases blood flow and lowers blood pressure.
  • Pulmonary Hypertension: Tadalafil and Sildenafil are also used to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs.

Benefits for Blood Pressure:

  • Vasodilation: These drugs cause blood vessels to widen, reducing the resistance the heart has to work against.
  • Improved Circulation: Enhanced blood flow can help lower systemic blood pressure.

Key Points:

  • Tadalafil: Known for its long half-life, providing extended relief.
  • Sildenafil: Shorter half-life, often used for acute management.

Other Medications That Lower Blood Pressure

In addition to PDE5 inhibitors, several other medications are commonly used to manage high blood pressure:

  1. ACE Inhibitors (e.g., Lisinopril)
  • Mechanism: Block the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.
  • Effect: Reduce blood vessel tension and volume, lowering blood pressure.
  1. Beta-Blockers (e.g., Atenolol)
  • Mechanism: Block beta-adrenergic receptors, reducing heart rate and output.
  • Effect: Decrease the heart’s workload and lower blood pressure.
  1. Calcium Channel Blockers (e.g., Amlodipine)
  • Mechanism: Inhibit calcium ions from entering heart and blood vessel walls.
  • Effect: Relax blood vessels, reducing blood pressure.
  1. Diuretics (e.g., Hydrochlorothiazide)
  • Mechanism: Increase urine output to remove excess sodium and fluid from the body.
  • Effect: Lower blood volume, reducing blood pressure.
DrugClassMechanismKey Benefits
TadalafilPDE5 InhibitorVasodilationLong-lasting effects
SildenafilPDE5 InhibitorVasodilationQuick onset
LisinoprilACE InhibitorBlocks angiotensin II productionLowers blood vessel tension
AtenololBeta-BlockerReduces heart rate and outputDecreases heart workload
AmlodipineCalcium Channel BlockerPrevents calcium entry into cellsRelaxes blood vessels
HydrochlorothiazideDiureticIncreases urine outputReduces blood volume


Understanding the various drugs that can help reduce blood pressure provides a comprehensive approach to managing hypertension, especially for those using SARMs or other performance-enhancing substances. By combining medical treatments with healthy lifestyle practices, you can effectively maintain your cardiovascular health.

For more information on managing blood pressure and related topics, explore our articles on SARMs for Strength, RAD 140 Gyno, and LGD 4033 Dosage.


Can Tadalafil be used for regular blood pressure management?

 Yes, Tadalafil can help manage pulmonary arterial hypertension and has been shown to lower systemic blood pressure due to its vasodilating effects.

Is it safe to use blood pressure medications with SARMs?

Empirically, yes. Consult with a healthcare provider before combining blood pressure medications with SARMs to ensure there are no adverse interactions.

What lifestyle changes can help reduce blood pressure?

Adopting a healthy diet, regular exercise, stress management techniques, and avoiding excessive sodium can significantly help in managing blood pressure.

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