SERMs: An Overview Of Our Products!
All Pros And Cons Together In One Article!
What Is A SERM?
SERMs, also known as Selective Estrogen Receptor Modulators, are a class of drugs that exert antagonistic (and sometimes agonistic) actions on the estrogen receptor.
Therefore, they are primarily used for the treatment of estrogen-related diseases such as osteoporosis, infertility, and breast cancer in women.
Some people refer to SERMs as designer estrogen because they can offer many of estrogen’s benefits without some of its other effects.
In other words, unlike estrogens that act as estrogen receptor agonists, SERMs have the ability to act selectively as agonists or antagonists depending on a target gene or tissue.
For example, they can help to prevent bone loss without stimulating the endometrial lining of the uterus.
So Why Could A Serm Be Useful For Men?
SERMs can stimulate endogenous Testosterone production in males by blocking the hypothalamic estrogen receptor.
This action tricks the brain into thinking that estrogen levels are low.
Estrogen is primarily acquired through the aromatization of testosterone so the hypothalamus will stimulate the release of LH and FSH.
In the end, that will boost testosterone levels.
SERMs may also be beneficial to treat male infertility. Because of the boost in LH and FSH, sperm count will improve as well.
Which SERMs Can We Offer You And How To Choose?
At Rats Army we have 3 SERMs in our product range: Clomiphene, Tamoxifen, and Raloxifene.
A few weeks ago we had an article about some of our products that are available as tablets.
Well, our 3 SERMs are available in liquid form (in all flavors – also winter flavors) as well as in tablet form.
The SERMs are all FDA approved for some while, starting with Clomiphene in the ’60s. So overall they are safe to use for research goals.
The oldest SERM around is Clomiphene. It was approved in 1967 for human use.
Clomid (Clomiphene Citrate) is a powerfully effective anti-estrogen.
Clomiphene Citrate is a SERM that is specifically used as a fertility aid due to its ability to enhance the release of gonadotropins. Clomid has the ability to oppose the negative feedback of estrogens on the Hypothalamic-Pituitary-Ovarian-Axis. This will increase the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH).
Clomid also carries strong anti-estrogen properties. By supplementing with Clomid during anabolic steroid use, the SERM will bind to the estrogen receptors, therefore inhibiting the estrogen hormone from binding. This can be very useful in combating gynecomastia and it can also have a positive impact on water retention. It can also have a positive effect on cholesterol levels.
By increasing LH and FSH levels, it will also increase testosterone levels.
Boosts testosterone (strongest of our 3 SERMs)
Tamoxifen is as well one of the older SERMs that has been approved for human use in 1977.
It is very similar to Clomiphene in how it works in the body.
For its anti-estrogen properties, it binds better to the mammary tissue.
That’s the biggest difference with Clomiphene.
It’s also better tolerated concerning side effects.
Boosts testosterone (less pronounced than Chlomid)
Less annoying side effects than Clomiphene
Raloxifene is one of the newer anti-estrogens on the market. It was ‘only’ approved in 1997 for human use.
It works very similarly to both Clomiphene and Tamoxifen, but there is less ‘clinical’ data concerning its use.
Raloxifene is less effective in boosting testosterone levels again compared to Clomiphene and Tamoxifen.
On the other hand, it’s highly effective in fighting gynecomastia and it even can reverse it!
Raloxifene has virtually no side effects.
Prevents and reverses gynecomastia
A mild increase in testosterone levels
No particular side effects
Clomiphene and Tamoxifen are the best choices after a research project.
Clomiphene has more side effects but is stronger in terms of increasing testosterone levels.
Most test subjects tolerate Tamoxifen better but it is less strong in restoring testosterone levels.
For suppressive research, you might want to choose Clomiphene (or even both Clomiphene and Tamoxifen).
It excels at fighting gynecomastia from the start.
Raloxifene can be used with mild research but is best used to fight existing gynecomastia.