SERMs: An Overview Of Our Products!
All Pros And Cons Together In One Article!
What Is A SERM?
SERMs, also known as Selective Estrogen Receptor Modulators, are a class of drugs that exert antagonistic (and sometimes agonistic) actions on the estrogen receptor.
Therefore, they are primarily used for the treatment of estrogen-related diseases such as osteoporosis, infertility, and breast cancer in women.
Some people refer to SERMs as designer estrogen because they can offer many of estrogen’s benefits without some of its other effects.
In other words, unlike estrogens that act as estrogen receptor agonists, SERMs have the ability to act selectively as agonists or antagonists depending on a target gene or tissue.
For example, they can help to prevent bone loss without stimulating the endometrial lining of the uterus.
So Why Could A Serm Be Useful For Men?
SERMs can stimulate endogenous Testosterone production in males by blocking the hypothalamic estrogen receptor.
This action tricks the brain into thinking that estrogen levels are low. Estrogen is primarily acquired through the aromatization of testosterone so the hypothalamus will stimulate the release of LH and FSH.
In the end, that will boost testosterone levels.
So it might be very useful to have it when you research with compounds that might suppress your own endogenous testosterone levels
SERMs may also be beneficial to treat male infertility. Because of the boost in LH and FSH, sperm count will improve as well.
So that is an extra positive effect it might do!
Which SERMs Can We Offer You And How To Choose?
At Rats Army we have 3 SERMs in our product range: Clomiphene, Tamoxifen, and Raloxifene.
A few weeks ago we had an article about some of our products that are available as tablets.
Well, our 3 SERMs are available in liquid form (in all flavors – also winter flavors) as well as in tablet form.
The SERMs are all FDA approved for some while, starting with Clomiphene in the ’60s. So overall they are safe to use for your research if you understand how and why to use them.
Most SERMs have the same side effects that include: upset stomach, hot flashes, mood swings… It depends on which SERM you choose which side effects will be more likely.
Keep in mind that these are powerful compounds: so handle with care!
The oldest SERM around is Clomiphene. It was approved in 1967 for human use.
Clomid (Clomiphene Citrate) is a powerfully effective anti-estrogen. It is still the most popular SERM as PCT for anabolic steroid users.
Clomiphene Citrate is a SERM that is specifically used as a fertility aid due to its ability to enhance the release of gonadotropins. Clomid has the ability to oppose the negative feedback of estrogens on the Hypothalamic-Pituitary-Ovarian-Axis. This will increase the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH).
Clomid also carries strong anti-estrogen properties. By supplementing with Clomid during anabolic steroid use, the SERM will bind to the estrogen receptors, therefore inhibiting the estrogen hormone from binding. This can be very useful in combating gynecomastia and it can also have a positive impact on water retention. It can also have a positive effect on cholesterol levels.
By increasing LH and FSH levels, it will also increase testosterone levels, which is very important after a suppressive cycle.
Boosts testosterone (strongest of our 3 SERMs)
Tamoxifen is as well one of the older SERMs that has been approved for human use in 1977.
It is very similar to Clomiphene in how it works in the body.
For its anti-estrogen properties, it binds better to the mammary tissue. In our concern, this means Tamoxifen is better at stopping gyno from the very start!
That’s the biggest difference with Clomiphene.
It’s also better tolerated concerning side effects.
Fights and stops gyno from the start
Boosts testosterone (less pronounced than Chlomid)
Less annoying side effects than Clomiphene
Mood swings (very rare)
Raloxifene is one of the newer anti-estrogens on the market. It was ‘only’ approved in 1997 for human use.
It works very similarly to both Clomiphene and Tamoxifen, but there is less ‘clinical’ data concerning its use as a PCT after researching suppressing compounds.
Raloxifene is less effective in boosting testosterone levels again compared to Clomiphene and Tamoxifen. So as a PCT you should only use it after mild cycles.
On the other hand, it’s highly effective in fighting gyno and it even can reverse long-existing gyno!
Raloxifene has virtually no side effects so that is a nice benefit as well!
Prevents and reverses gyno
A mild increase in testosterone levels
No particular side effects
Less effective as PCT to restore testosterone levels
As a PCT Clomiphene and Tamoxifen are the best choices. Clomiphene has more side effects but is stronger in terms of increasing testosterone levels.
Most users tolerate Tamoxifen better but it is less strong as PCT in restoring testosterone levels. For suppressive cycles, you might want to choose Clomiphene (or even both Clomiphene and Tamoxifen).
It excels at fighting gyno from the start.
Raloxifene can be used with mild cycles as PCT but is best used to fight existing gyno. You can combine it with one of the other SERM in a PCT cycle.