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Raloxifene is a SERM that exhibits estrogenic effects on bone and lipid metabolism. So in normal language it does protect your bones and increases your bone mineral density. It also lowers your LDL (bad cholesterol).
It inhibits anti-estrogenic effect on breast tissue and uterine endometrium. So again in other words it blocks estrogenic effects on these tissues and does it in a better way than Tamoxifen in terms of regression of the mammary gland. So it’s the best SERM to combat gyno.
Raloxifene has a half-life from 27 up to 32 hours and is well absorbed by oral administration (this goes even up when administered with a high-fat meal). Dosage is at 30-60mg/day.
Raloxifene is FDA approved and comes with a minimum of sides: may lower IGF1-levels, may cause nausea and hot flashes, can upset your stomach… Like with other SERMS.
Main source: https://go.drugbank.com/drugs/DB00481
Excells in gyno-treatment
Lowers bad cholesterol
May Lower IGF1-levels
May cause hot flashes and nausea
Other common SERM-sides like stomach upset…
Exemestane is also well known under the name Aromasin and is a aromatase inhibitor. It will prevent estrogen to be formed in the adrenal glands without interfering with other hormonal functions.
The best use for Exemestane is for controlling estrogen levels so they don’t shoot out of the roof or don’t end up high when your testosterone levels are low.
Exemestane is FDA approved and has a half-life of 24 hours. It is dosed at 25mg/day at max. You should always take it with a meal!
It is a great alternative to Arimidex because it has a less strong effect on aromatase inhibition and so a greater margin of error (you will not crash your estrogen by accident). So if you are less experienced with AI’s then this is the product for you.
It also comes with less common side effects than Arimidex: no high blood pressure, no rash, no cold like symptoms and it doesn’t interact with Tamoxifen.
Controls estrogen levels Less powerful than Arimidex
Well tolerated/ almost no sides
Doesn’t effect blood pressure
No interaction with Tamoxifen
May cause hot flashes and nausea
Fatigue/ sleeping difficulties
Controls estrogen levels
Less powerful than Arimidex
Laxogenin is a very interesting compound with a lot of interesting properties. It belongs to a class of plant hormones called brassinosteroids. So Laxogenin is no prohormone or steroid and can be used as a supplement. It works non-hormonal so it can be incorporated in a PCT for better recovery.
Laxogenin works well for muscle building: it increases protein production in muscles (up to 200%) and prevents breakdown of muscle proteins. It also might reduce blood sugar, prevent tissue damage and protect you from cancer.
Laxogenin gets ton of positive reviews all over the internet but there aren’t any clinical trials, only cell and animal studies. It is also believed than most Laxogenin products are bunk or bad quality! (that’s of course no problem for Rat’s Army’s Laxogenin)
Laxogenin comes with almost no side effects except for stomach upset. You should watch out if you have a bad history with kidney problems…
It is not FDA approved but FDA is looking into it! Dosage is best set at 100mg per day and can be taken on an empty stomach.
Main source: https://selfhacked.com/blog/laxogenin/
Safe / virtually no sides
Decent muscle gains
Non-hormonal so useful in PCT
No clinical trials or studies
Hard to find good quality