ANDARINE (S4): REVIEW, DOSAGE, PCT & MORE IN 2023

WHAT IS ANDARINE (S4)?

Andarine (also known as S-4, S4, Androxolutamide, and GTx-007) was one of the first SARMs ever developed. It used to be very popular back when SARMs first gained traction, but in recent years it has lost that prestige.

Like Ostarine, it was developed by GTx, Inc. for the treatment of muscle wasting conditions and osteoporosis. It has also been proven to be effective at reducing prostate size in rats with Benign Prostatic Hyperplasia (BPH).

Unfortunately, Andarine was abandoned and it never reached Phase I Clinical Trials. This means that we have no scientific data on the effects of Andarine on humans, but it has been used recreationally by so many users, that we have plenty of anecdotal information to go by.

BUY ANDARINE S4

Click on the link below to buy our recommended Andarine (S4) and save 10% OFF with code ENH10 at checkout!
BUY ANDARINE S4

BUY ANDARINE S4

Click on the link below to buy our recommended Andarine (S4)and save 10% OFF with code ENH10 at checkout!

ANDARINE (S4) HISTORY

The pharmaceutical company responsible for the development of Andarine S-4 is GTx, Inc. They originally developed it for the treatment of muscle wasting conditions and osteoporosis approximately 20 years ago. Since then, it has been abandoned while other SARMs like Ostarine (MK-2866) carry on further studies.

In a 2002 in vivo study with castrated rats, Andarine S4 showed a dose-dependent improvement in total lean body mass and physical function and was well tolerated. [R]

HOW TO BUY ANDARINE (S4) LEGALLY

Andarine S4 is a legal performance enhancing drug. Given that is has not been approved by the FDA, Andarine can be classified as a research chemical. Research chemicals are completely legal to buy and sell online and over-the-counter, as long as they are being marketed as research products for laboratory use only and not for human consumption.

You can find high-quality, 3rd-party purity-tested Andarine S4 for SALE by clicking in the link below. Use code ENH10 to save 10%!

HOW DOES ANDARINE (S4) WORK?

Like all SARMs, Andarine S4 works by attaching to the androgen receptor in muscle tissue and bones. There, it stimulates protein synthesis to accelerate muscle growth and bone density. 

This mechanism of action is similar to that of Anabolic Steroids, but the difference is that Anabolic Steroids are not selective and they attach to androgen receptors in all kinds of tissues, whereas SARMs are as selective for muscle and bone mass as possible.

MECHANISM OF ACTION OF SARMS

ANDARINE PROS & CONS IN A NUTSHELL

PROS:

  • MILDLY ANABOLIC
  • WILL IMPROVE STRENGTH NOTICEABLY
  • WILL PROVIDE A DRY, HARD AND VASCULAR LOOK
  • WILL INCREASE BONE DENSITY AND JOINT STRENGTH
  • SENSE OF WELL-BEING (EUPHORIA)

CONS:

  • WILL SUPPRESS TESTOSTERONE LEVELS (TO A SMALL EXTENT COMPARED TO OTHER ANABOLICS)
  • WILL CAUSE DYSLIPIDEMIA
  • WILL CAUSE MILD LIVER TOXICITY
  • CAN CAUSE TEMPORARY EYE ADAPTATION IMPAIRMENT (TO LIGHT)

BENEFITS OF ANDARINE (S4)

The benefits of Andarine have turned this otherwise mild therapeutic solution for muscle wasting diseases into a great performance enhancing drug and anabolic for beginners.

These are the main benefits of Andarine (S4):

FAST MUSCLE GROWTH

While Andarine is clearly effective at building lean muscle mass, it is not what it excels at. The anabolism of Andarine is comparable to that of Ostarine, with both drugs building similar amounts of muscle at their recommended doses.
Like all SARMs, however, it will preserve and even increase muscle mass while on a caloric deficit. [R]
 

STRENGTH INCREASE

You can expect Andarine to improve your strength and performance at the gym significantly. It is hard to tell exactly where S-4 ranks against other SARMs in terms of boosting strength, but people often report greater strength gains on Andarine than on Ostarine. If your priority is strength but you want to avoid the harsher SARMs, Andarine is the best option. [R]
 

BETTER FAT LOSS AND VASCULARITY

Contrary to what some people claim, Andarine will not make you lose more fat. However, since it is a dry SARM, it will make you look leaner and tighter than you really are.
 
Like all SARMs, it is excellent at keeping muscle mass and even increasing it while on a caloric deficit.
 

INCREASE BONE DENSITY & JOINT STRENGTH

Andarine will increase your bone density, after all that is partly what it was developed for. Unfortunately, it does not have the joint-healing benefits of Ostarine, which further explains why the latter is more popular. Fortunately, it does not tend to cause dry joints despite being a dry compound. [R]
 

RECOVERY

Andarine will speed up your recovery and reduce muscle soreness, so you can expect your muscles to be fully recovered and ready to be worked out again much sooner than if you were natural.
 

COSMETIC BENEFITS

The cosmetic benefits of Andarine are the only reason why some people still choose to run it. This compound is known for providing a very dry, vascular and tight look, making it a perfect choice for contest prep and photoshoots.

Pumps are also significantly better, and you can expect a 3D look that some people define as “Winstrol-lite”.
 

OTHER BENEFITS

 

REDUCE PROSTATE SIZE

There is some data indicating that S-4 may be able to shrink the prostate, similar to what RAD-140 can do.

The data on this benefit is extremely limited and it was studied on rodents, so take it with a grain of salt.

It is also worth noting that many users claim that Andarine made them happier and improved their mood, but the mechanism of action behind that possible benefit is completely unknown. [R]

SIDE-EFFECTS OF ANDARINE (S4)

Unfortunately, Ostarine is not side-effect-free. The amazing benefits you just learned about come with some negatives, but thankfully Ostarine is one of the safest SARMs and performance enhancing drugs you can use, so it’s fair to say that the pros outweigh the following cons:

TESTOSTERONE SUPPRESSION

Andarine, like all SARMs, will cause a significant drop in your Testosterone levels. Fortunately, Andarine is one of the least suppressive SARMs out there so this side effect is very manageable and easily reversible. Suppression from Andarine is comparable to that of Ostarine.

The consequences of this drop in your testosterone levels can be:
  • Decreased libido
  • Weaker erections
  • Lethargy
  • Lack of motivation
  • Irritability
  • Testicular atrophy
  • Testicular pain

Thankfully, most users do not experience more than a couple of these and only for a very limited amount of time, usually by the end of the cycle and during the first week or two after the cycle is over.

It is worth noting that Andarine, like all SARMs, will decrease your SHBG. This will lead to an increase in your free testosterone levels which usually causes libido, motivation and well-being to improve during the first few weeks of the cycle, until the suppression of the Total Testosterone levels offsets the increase in Free Testosterone. [R]
 

DYSLIPIDEMIA

Andarine, like all SARMs, will cause dyslipidemia. Your HDL (good) cholesterol will decrease significantly, and your LDL (bad) cholesterol will increase.
This side-effect will not manifest itself by impacting the way you feel, so you will have no symptoms. Getting bloodwork at the end of a cycle will show the true impact of the SARM on your lipid panel.
 

VISION SIDE EFFECTS

The one thing that puts most people away from Andarine is the fact that it can affect the user’s vision.
 
As crazy as it sounds, S-4 will give a yellowish tint to your eyes while making it harder for you to adapt to lighting changes and reducing your ability to see in dark settings.

Fortunately, these problems disappear after the cycle is over and according to most users, they are easy to get used to and they do not impair vision to a significant extent during the cycle. Still, this side-effect is no joke and it should not be taken lightly.

This side-effect is user and dose dependent, with most people reporting that it occurs when taking 50mg/day or more. We’ll show you down below how you can further mitigate this side-effect in a non-dose-dependent manner.
 

LIVER TOXICITY

Even though there is no scientific evidence to prove that S-4 is hepatotoxic, it is not rare for bloodwork to show elevated liver enzymes after a cycle, so expect that outcome.
 

OTHER SIDE-EFFECTS

The three side effects we just touched upon will impact almost every user, but there are some side effects that only happen to an extremely small minority of people.


Gynecomastia

The growth of breast tissue on males. This is an extremely rare side effect that is caused by an imbalance between your estrogen and testosterone levels. Men who have had pubertal gynecomastia are at risk of developing it if they take Andarine.
 

Hair shedding

This side effect is even rarer than the previous one, and thankfully it only seems to be temporary and completely reversible. Any substance that interferes with your hormonal levels has the potential of causing hair shedding, and Andarine is no exception.


Insomnia

This is another rare side-effect that some people experience. This one is entirely unpredictable but can be mitigated easily.

SARMs impact everyone differently. You may get horrible vision side-effects and go temporarily blind and your friend may have zero vision problems; you never know until you experiment.
 

HOW TO AVOID & REVERSE SIDE-EFFECTS

Managing the side-effects of Andarine (S4) during a cycle is easier than it seems. Having a clean diet, doing your cardio, avoiding alcohol and sleeping right will help a lot, but some rare possible side-effects like man boobs, hair loss and acne require special protocols.
 

AVOIDING VISION SIDE EFFECTS

Andarine (S4) has a very short half life of about 4-6 hours. We’ve found through our own personal research and others some empirical evidence to help mitigate the unwanted eye adaptation impairment.

Since the half-life of Andarine is so short, it’s at 99% efficacy within just a few days. A protocol many have found that works is by simply taking Andarine 3x/day (as normal) Monday through Friday and taking Saturday and Sunday off.

Essentially, this gets much of the Andarine out of the system and forces the chemical to regain much of its efficacy, not allowing it as much time to attempt agonization of the receptors near the eye.

FURTHER AVOIDING SIDE-EFFECTS

If you are planning to do an Andarine (S4) cycle and you want to make sure your results are as good as possible while minimizing all side-effects and preventing the nasty side-effects like gynecomastia, erectile dysfunction, and hair-loss, you need to read THE SARM HANDBOOK by @enhancedinfo.
 
This best-selling eBook by enhancedinfo has truly become the No.1 book about SARMs ever written, with over 7000 copies sold and close to 300 5-star reviews, all for the price of a basic menu at McDonalds. Click on the link below to read it!

ANDARINE (S4) DOSAGE FOR BODYBUILDING

Bodybuilders use anywhere from 25mg to 75mg a day, but the sweetspot that most male users prefer is 50mg a day.  Do your due diligence to remember how short the half-life of this chemical is and take the 1/3 daily dose 3x per day. For example, if you choose 45mg/day as your dose, you would take 15mg every 6 hours.

Some users have tried doses of up to 75mg a day but the benefits don’t seem to get any better past 50mg a day and only the side-effects increased, especially the vision side-effects.

Female users can get amazing results with as little as 25mg a day, and they should never use more than 50mg a day.

HOW TO CYCLE ANDARINE (S4)

The most common Andarine (S4) cycle consists of 50mg a day, taken for a total of 8 weeks. The shortest Andarine cycles are usually around 6 weeks and the longest ones can last for up to 12 weeks. 

We really believe that 50mg a day for 8 weeks is the best approach to using Andarine, since it’s a protocol that allows most people to get amazing results without experiencing seriously nasty side-effects.

These cycles are usually followed by a 4 week Post-Cycle Therapy.

ANDARINE (S4) POST-CYCLE THERAPY (PCT)

Since Andarine can suppress testosterone levels to a potentially large extent, we recommend all users to do a Post-Cycle Therapy (PCT) after an Andarine cycle to restore natural testosterone levels and ensure the retention of muscle gains, strength and optimal sexual function.

The typical Andarine S4 PCT consists of 4 weeks of Tamoxifen (Nolvadex) or Enclomiphene (Androxal) use. You can learn more about the ideal PCT for SARMs here.

If you’re wondering where to buy Tamoxifen and which is the #1 SARMs website to purchase it from, we highly recommend Swiss Chems. Their high-quality products are second to none, and their shipping is ALWAYS on time.

ANDARINE (S4) TL:DR

In a nutshell, we could say that Andarine (S4) is an incredibly effective and quite safe SARM that will build a modest but significant amount of muscle mass and strength without causing a ton of side-effects.

This is an excellent option for beginners who want to get their feet wet with PEDs but also for experienced enhanced lifters who simply want to use something mild that will still provide great results.

Take Andarine 3x per day every 6 hours Monday through Friday to avoid unwanted vision (yellow vision tint) side-effects.

WHERE TO BUY ANDARINE (S4)

If you decide to do an Andarine cycle, choosing a reliable company to buy from is crucial, since buying it from a bad company could result in you getting no results or getting horrible side-effects due to being sold something that’s not actually Andarine (which is very often counterfeited). 

We recommend going with Chemyo Andarine S4.

All of their SARMs vials come in 50 ml (milliliter) bottles, which is a full 20 ml more than the industry standard of 30 ml—that’s a 66% increase in the value you’re getting with these products.

Key benefits of Chemyo:

  • Third Party Testing
  • Very Good Prices
  • Responsive Customer Support
  • Wide Range of Products
  • Big Cryptocurrency Discount

They have been in the game for half a decade and have truly become one of the most reputable and most respected providers for 99.9% pure SARMs and other research chemicals.

You can buy Andarine from them through the link below and use code ENH10 to save 10% off your order

ANDARINE (S4) FAQs

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