WHAT IS S-23?
S-23 is perhaps the most powerful cutting SARM on the market today. Despite seeming very promising and attractive on paper, S-23 is quickly becoming one of the least popular and most overlooked drugs in its category, with people choosing other SARMs and oral AAS instead.
It was developed by GTx, Inc. but unlike other SARMs by this company, it was not developed to treat muscle wasting conditions or osteoporosis. Instead, it was developed as a potential form of oral contraception for males. It never reached clinical trials, so we have no scientific data about the effects of S-23 on humans.
BUY S-23

BUY S-23
S-23 SARM HISTORY
The pharmaceutical company responsible for the development of S-23 is GTx, Inc (they’re quite responsible for a lot of SARMs, actually). They originally developed it as a male contraceptive approximately 15 years ago. Since then, it has been forgotten.
In a 2008 in vitro study (test tubes) with castrated rats, S-23 showed a dose-dependent improvement in total lean body mass, increased bone density, reduced fat mass, and was well tolerated. [R]
HOW TO BUY S-23 LEGALLY
S-23 is a SARM and is a legal performance enhancing drug. Given that is has not been approved by the FDA, S-23 can be classified as a research chemical. Research chemicals are completely legal to buy and sell online and over-the-counter, as long as they are being marketed as research products for laboratory use only and not for human consumption.
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HOW DOES the S-23 SARM WORK?
Like all SARMs, S-23 works by attaching to the androgen receptor in muscle tissue and bones. There, it stimulates protein synthesis to accelerate muscle growth and bone density.
This mechanism of action is similar to that of Anabolic Steroids, but the difference is that Anabolic Steroids are not selective and they attach to androgen receptors in all kinds of tissues, whereas SARMs are as selective for muscle and bone mass as possible.

S-23 PROS & CONS IN A NUTSHELL
PROS:
- VERY ANABOLIC
- WILL IMPROVE STRENGTH NOTICEABLY
- WILL PROVIDE A DRY, HARD AND VASCULAR LOOK
- WILL INCREASE BONE DENSITY AND JOINT STRENGTH
CONS:
- WILL SUPPRESS TESTOSTERONE LEVELS (TO A SMALL EXTENT COMPARED TO OTHER ANABOLICS)
- WILL CAUSE DYSLIPIDEMIA
- MAY CAUSE MILD LIVER TOXICITY
- WILL CAUSE INFERTILITY
BENEFITS OF S-23
The benefits of S-23 have turned this male contraceptive into a great performance enhancing drug and anabolic for intermediate and advanced enhanced lifters.
These are the main benefits of S-23:
FAST MUSCLE GROWTH
STRENGTH INCREASE
On the other hand, we have people who experience a serious drop in strength and performance when cutting, partly due to S-23 being harsh on the joints and partly due to the alleged ability of S-23 to rapidly burn through glycogen, something that leaves users feeling extremely depleted and looking seriously flat. [R]
FAT LOSS
We cannot extrapolate this information and confirm that this phenomenon applies to humans as well, but many users claim that S-23 increases metabolism so much, that it can boost fat loss. Take that information with a grain of salt. [R]
INCREASE BONE DENSITY & JOINT STRENGTH
RECOVERY
COSMETIC BENEFITS
From reviewing anecdotal information, we can see that the cosmetic benefits are like those of steroids such as Winstrol and Masteron, so one can expect an extremely dry and vascular look when cycling S-23.
Unfortunately, the muscle flatness that it can cause in the absence of sufficient carbohydrates can compromise the look of users who are trying to look fuller and bigger.
OTHER BENEFITS
CONTRACEPTION AND SEXUAL DESIRE
SIDE-EFFECTS S-23
Unfortunately, S-23 is not side-effect-free. The amazing benefits you just learned about come with some potentially harsh negatives.
TESTOSTERONE SUPPRESSION
- Decreased libido
- Weaker erections
- Lethargy
- Lack of motivation
- Irritability
- Testicular atrophy
- Testicular pain
DYSLIPIDEMIA
LIVER TOXICITY
ANDROGENIC SIDE-EFFECTS
On paper S-23 should not be androgenic, but hundreds of users report androgenic side-effects such as hair loss, acne and aggression. It is unclear why S-23 has androgenic properties.
INCREASED BODY TEMPERATURE
Some users report increased body temperature, so excessive sweating, night sweats, dehydration and cramps can easily happen.
OTHER SIDE-EFFECTS
Gynecomastia
Hair shedding
Insomnia
HOW TO AVOID & REVERSE SIDE-EFFECTS
AVOIDING SIDE-EFFECTS
S-23 SARM DOSAGE FOR BODYBUILDING
Bodybuilders use anywhere from 10mg to 30mg a day of S-23 but the sweetspot that most male users prefer is 20mg a day. Do your due diligence to remember the half-life of S-23 is unclear but most take it twice per day. For example, if you choose 20mg/day as your dose, you would take 10mg every 12 hours.
Female users can get amazing results with as little as 10mg a day, and they should never use more than 20mg a day.
HOW TO CYCLE S-23
The most common S-23 cycle consists of 20mg, split twice a day, taken for a total of 8 weeks. The shortest S-23 cycles are usually around 4 weeks and the longest ones can last for up to 10 weeks.
We really believe that 20mg a day for 8 weeks is the best approach to using S-23, since it’s a protocol that allows most people to get amazing results without experiencing seriously nasty side-effects.
These cycles are usually followed by a 4 week Post-Cycle Therapy.
S-23 ON-CYCLE THERAPY
It’s imperative you use a testosterone base with your S-23.
We can’t recommend Amino Asylum Enclomiphene enough. While using S-23, a simple 12.5mg/day protocol of Enclomiphene can help keep your testosterone levels balanced, not causing any of the nasty symptoms from suppression or worse, a crash.
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S-23 POST-CYCLE THERAPY (PCT)
Since S-23 can suppress testosterone levels to a potentially large extent or even cause a shutdown, we recommend all users to do a Post-Cycle Therapy (PCT) after a S-23 cycle to restore natural testosterone levels and ensure the retention of muscle gains, strength, and optimal sexual function.
The typical S-23 PCT consists of 4 weeks of Clomiphene (Clomid) or Enclomiphene (Androxal) use. You can learn more about the ideal PCT for SARMs here.
S-23 SARM TL:DR
In a nutshell, we could say that S-23 is an incredibly effective SARM that will build a modest amount of muscle mass and strength.
This is an excellent option for intermediates who want to get their feet wet with stronger PEDs but also for experienced, enhanced lifters who simply want to use something milder than an AAS (Steroid) that will still provide great results.
Take S-23 2x per day every 12 hours.
WHERE TO BUY S-23
If you decide to research with the S23 SARM, choosing a reliable company to buy from is crucial, since buying it from a bad company could result in you getting no results or getting horrible side-effects due to being sold something that’s not actually S-23.
We recommend going with Chemyo’s S-23 SARM.
All of their SARMs vials come in 50 ml (milliliter) bottles, which is a full 20 ml more than the industry standard of 30 ml—that’s a 66% increase in the value you’re getting with these products.
Key benefits of Chemyo:
- Third Party Testing
- Very Good Prices
- Responsive Customer Support
- Wide Range of Products
- Big Cryptocurrency Discount
They have been in the game for half a decade and have truly become one of the most reputable and most respected providers for 99.9% pure SARMs and other research chemicals.
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